Best practice for return statements in Python [closed]

I am wondering what are the best practices for return statements. In particular, is it ok to create an intermediate variable right before a return statement if I can otherwise bypass the variable and have the return statement followed by the value to return?

Example:

def add_me(a=1,b=2,c=3,d=4):
    e = a + b + c + d
    return e

or would it be better to do:

def add_me(a=1,b=2,c=3,d=4):
    return a + b + c + d

What about multiple function calls:

def sub_me=1,b=2,c=3,d=4):
    return a - b - c - d

def add_me(a=1,b=2,c=3,d=4):
    return a + b + c + d + sub_me() + 1