“Thinking in KnockOutJS” if I have a jQuery background?

I want to hear well-known (between experts) facts, that become obvious only after getting bad experience. I want to prevent months of bad practice and waste of time.

• What's difference in coding philosophy
• Best practices
• Design patterns for application without backend
• Design patterns for application with backend
• Working with AJAX
• Debug best practices
• Newbie mistakes
• Never do like: ...
• Every application start with: ...
• Fundamental structure (files tree and code design ( it's like a classes, voids or?...))

I know there is great tutorial for it, but when I started using it - I understood how simplified tutorials are and had stuck with many of real world problems. I want to receive very detailed answer with FACTS only. Something like there: "Thinking in AngularJS" if I have a jQuery background? , but short lists of facts with detailed explanation.