GUI Framework based on Open GL

I have an idea to create simple cross-platform GUI framework, which will use Open GL for rendering. I want to use Open TK library for C#. How to achieve better performance using Open GL (is there any best practices etc). What pattern is better to follow: MVVM, MVP, MVC, or something else? How to handle UI events? How to implement the ability to use platform-specific features? How to organize dependency injection? I would hear some advice from people who had an experience in this area. Thank You.